Diisopropylamine → HCID 59548367、化合物

温度

-78 °C

Diisopropylamine (4.60 mL, 32.5 mmol) was dissolved in THF (80 mL) and cooled in an ice water bath. Then, n-butyllithium solution (1.6 M in hexanes, 21.0 mL, 33.6 mmol) was added via syringe. After 30 minutes, the reaction was cooled to −78° C. and 5-(1,3-dioxolan-2-yl)-2-fluoropyridine (3.73 g, 22.1 mmol) was added as a solution in THF (12 mL) dropwise over 5 minutes via syringe, followed by a THF (4 mL) rinse. The reaction was stirred at −78° C. under nitrogen for 1 hour, and then triisopropyl borate (Fluka 98+%, 8.0 mL, 34.9 mmol) was added via syringe, and the reaction was allowed to warm up to room temperature. After 4.5 hours, the reaction was quenched with 1 N NaOH (75 mL). The layers were separated, and the aqueous phase was treated with 5N HCl to lower the pH to between 6 and 7. The aqueous phase was extracted with 10:1 DCM/MeOH. 5N HCl was added to the aqueous phase to lower the pH to about 5, and extraction was continued with 10:1 DCM/MeOH. The organic extracts were combined, concentrated and dried under high vacuum to give 5-(1,3-dioxolan-2-yl)-2-fluoropyridin-3-ylboronic acid (3.165 g, 91% purity, 61% yield over 2 steps). MS (ESI pos. ion) m/z 214 (M+H)+.

1. temperaturecooled in an ice water bath
2. washrinse
3. temperatureto warm up to room temperature
4. waitAfter 4.5 hours
5. customthe reaction was quenched with 1 N NaOH (75 mL)
6. customThe layers were separated
7. additionthe aqueous phase was treated with 5N HCl
8. extractionThe aqueous phase was extracted with 10:1 DCM/MeOH
9. addition5N HCl was added to the aqueous phase
10. extractionto about 5, and extraction
11. concentrationconcentrated
12. customdried under high vacuum

ORDレコード

ord-48027cb7671e41eeb4da2beef5b04447

出典データセット

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08772480B2