Phosphorus oxychloride → HCID 53407931、化合物

HRID 1622332

反応式

HRID 1622332 の反応式
[CH3:1][C:2]1[C:3](=O)[NH:4][CH:5]=[N:6][CH:7]=1.P(Cl)(Cl)([Cl:11])=O>>[ClH:11].[Cl:11][C:3]1[C:2]([CH3:1])=[CH:7][N:6]=[CH:5][N:4]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 2053244-Pyrimidinol, 5-methyl-

生成物 1

HCID 53407931HCID 53407931、化合物

反応条件

温度
90 °C

実験手順

A mixture of 5-methyl-3H-pyrimidin-4-one (0.60 g, 3.6 mmol) and phosphorous oxychloride (2.0 mL) was heated at 90° C. for 2.5 h. The mixture was evaporated to dryness under reduced pressure and the resultant solid was purified by sublimation under reduced pressure to furnish the title compound as a white solid. This compound was unstable to air and was used immediately in the next step.

後処理

  1. customThe mixture was evaporated to dryness under reduced pressure
  2. customthe resultant solid was purified by sublimation under reduced pressure

出典と根拠

ORDレコード
ord-5c6992e2e2cc4d99b61018019e5c64be
出典データセット
uspto-grants-2014_07
特許番号
US08778925B2

関連ノート

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