Sodium Hydroxide → 2-Hydroxymethyl-3-methyl-4-propoxy-pyridine

HRID 1623580ノート

反応式

HRID 1623580 の反応式
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH3:16])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH3:16])[CH:9]=[CH:8][N:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 684689472-Acetoxymethyl-3-methyl-4-propoxy-pyridine

生成物 1

HCID 140971152-Hydroxymethyl-3-methyl-4-propoxy-pyridine収率 48.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

27.8 g of 2-acetoxymethyl-3-methyl-4-propoxy-pyridine was added dropwise into a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. Subsequently, the reaction liquid was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 11.0 g of 2-hydroxymethyl-3-methyl-4-propoxy-pyridine as an oily matter.

後処理

  1. customto react for one hour at room temperature
  2. customSubsequently, the reaction liquid
  3. washthe toluene phase was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-a41668ad33484ba3acc5aa1d60f20f7e
出典データセット
uspto-grants-2014_07
特許番号
US08778975B2

反応ノート

読み込み中…