Sodium Hydroxide → 4-Butoxy-3-methyl-2-pyridinemethanol

HRID 1623583ノート

反応式

HRID 1623583 の反応式
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH:9]=[CH:8][N:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 68469816HCID 68469816、化合物

生成物 1

HCID 684683474-Butoxy-3-methyl-2-pyridinemethanol収率 75.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

13.4 g of 2-acetoxymethyl-3-methyl-4-butoxy-pyridine was added dropwise to a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. The mixture was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 8.3 g of 2-hydroxymethyl-3-methyl-4-butoxy-pyridine as an oily matter.

後処理

  1. customto react for one hour at room temperature
  2. washthe toluene phase was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-34f3a2f9b7204100ae38ffa22b5dcef7
出典データセット
uspto-grants-2014_07
特許番号
US08778975B2

反応ノート

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