(S)-4-(1-Azido-2-(tert-butyldimethylsilyloxy)ethyl)pyridine → (S)-2-(tert-Butyldimethylsilyloxy)-1-(pyridin-4-yl)ethanamine
反応式
[N:1]([C@@H:4]([C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)[CH2:5][O:6][Si:7]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8])=[N+]=[N-]>CO.[Pd]>[Si:7]([O:6][CH2:5][C@H:4]([C:14]1[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=1)[NH2:1])([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]参加物
4
実験手順
10% Pd/C (10 mg) was added to (S)-4-(1-azido-2-(tert-butyldimethylsilyloxy)ethyl)pyridine (58 mg, 0.208 mmol) in methanol. The reaction was degassed, and then charged with hydrogen. The reaction was stirred at room temperature overnight and filtered. The filtrate was concentrated to give the title compound (50 mg) without further purification.
後処理
- customThe reaction was degassed
- additioncharged with hydrogen
- filtrationfiltered
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-ce31dcd50948496bacd5e965ecfdedde
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08778950B2
反応ノート
読み込み中…