戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1623980作成日：2026年10月25日

1-(Trifluoromethyl)cyclobutan-1-amine hydrochloride → (1aS,5aS)-2-Pyrazin-2-yl-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (1-Trifluoromethyl-cyclobutyl)-amide

https://huagongshe.com/reaction/1623980

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Trifluoromethyl)cyclobutan-1-amine hydrochlorideHCID 53415776—
反応物(4AS,5aS)-1-(pyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acidHCID 68004668—
生成物(1aS,5aS)-2-Pyrazin-2-yl-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (1-Trifluoromethyl-cyclobutyl)-amideHCID 51029727—

反応手順

The title compound was prepared in a manner similar to that described in Method UU using Intermediate 4 and 1-(trifluoromethyl)cyclobutanamine hydrochloride. LCMS m/z=364.4 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 0.47 (td, J=4.6, 3.2 Hz, 1H), 1.23-1.29 (m, 1H), 2.04-2.14 (m, 2H), 2.27-2.33 (m, 1H), 2.64-2.70 (m, 4H), 2.74-2.80 (m, 1H), 2.93 (d, J=16.9. Hz, 1H), 3.02 (dd, J=16.6 and 6.2 Hz, 1H), 6.99 (s, 1H), 8.42 (dd, J=2.5 and 1.5 Hz, 1H), 8.52 (d, J=2.5 Hz, 1H), 9.26 (d, J=1.4 Hz, 1H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08778950B2
出典データセットuspto-grants-2014_07
ORD IDord-e90b3c39af794dd2bf719e1c4aef83c6
出典メモuspto-grants-2014_07