HCID 86717937、化合物 → 2-Amino-4-fluoropyridin-3-ol
反応式
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11]>C(O)C.[Pd]>[NH2:8][C:4]1[C:3]([OH:11])=[C:2]([F:1])[CH:7]=[CH:6][N:5]=1参加物
4
実験手順
Under argon, 90 mg (0.57 mmol) of 4-fluoro-2-nitropyridin-3-ol Example 108A were dissolved in 30 ml of ethanol, and a spatula tip of palladium on activated carbon (10%) was added. The mixture was hydrogenated at RT under reduced pressure for 1.5 h. The reaction mixture was filtered off through silica gel and the filter cake was washed with plenty of ethanol. The solution was concentrated and dried. This gave 56 mg (77% of theory) of the title compound.
後処理
- filtrationThe reaction mixture was filtered off through silica gel
- washthe filter cake was washed with plenty of ethanol
- concentrationThe solution was concentrated
- customdried
出典と根拠
- ORDレコード
- ord-ab89a6b7b2954783916f3e6ee4525f5f
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08778964B2
反応ノート
読み込み中…