Hydrazine hydrate (1:1) → HCID 59436165、化合物

HRID 1624558ノート

反応式

HRID 1624558 の反応式
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([O:20]C)=O.O.[NH2:23][NH2:24]>C(O)C>[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([NH:23][NH2:24])=[O:20]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 1481306HCID 1481306、化合物

生成物 1

HCID 59436165HCID 59436165、化合物収率 60%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (1.019 g, 3.42 mmol) and hydrazine monohydrate (0.3 mL, 6.19 mmol) in ethanol (10 mL) was heated under microwave conditions for 10 min at 120° C. After that time, the reaction was cooled to room temperature and the product was collected by filtration and washed with cold ethanol to give 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carbohydrazide (0.607 g, 60%) as bright orange crystals.

後処理

  1. filtrationthe product was collected by filtration
  2. washwashed with cold ethanol

出典と根拠

ORDレコード
ord-5ecaf24b77e64ff2b651a557e225985f
出典データセット
uspto-grants-2014_07
特許番号
US08778944B2

反応ノート

読み込み中…