Sodium Hydroxide → HCID 178506294、化合物

反応式

P(Cl)(Cl)([Cl:3])=O.[F:6][C:7]([F:19])([F:18])[C:8]1[C:16]2[C:11](=[N+:12]([O-])[CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1.[OH-].[Na+]>>[Cl:3][C:15]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:10][N:9]=[C:8]([C:7]([F:19])([F:18])[F:6])[C:16]=12

参加物

反応物 3

HCID 14798Sodium Hydroxide

HCID 24813Phosphorus oxychloride

HCID 178526242HCID 178526242、化合物

生成物 1

HCID 178506294HCID 178506294、化合物収率 27%

反応条件

温度: 100 °C

実験手順

Phosphorus oxychloride (76.4 g) was gradually added to compound (1b) (33.2 g), followed by stirring at 100° C. for 1 hr. The reaction solution was poured into ice water, and sodium hydroxide was added thereto to adjust the pH to 10. The precipitate was collected by filtration to obtain compound (1c) (9.76 g, 27%) as a light pink solid.