Dichloromethane → 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

HRID 1625486ノート

反応式

HRID 1625486 の反応式
[Cl:1]CCl.[F:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](O)=[O:16])[C:10]1=[O:18].C(Cl)(C(Cl)=O)=O>CN(C=O)C>[F:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:8][N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([Cl:1])=[O:16])[C:10]1=[O:18]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 534279691-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

生成物 1

HCID 593623351-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The flask was charged with dichloromethane, 20 mg of 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, DMF, (COCl)2 was added slowly via syringe. Then the resulted mixture was allowed to stir at room temperature for 3 h. After TLC show the reaction was complete, the solvent was removed under high vacuum to give 25 mg of crude product, which was used for the next step reaction without further purification.

後処理

  1. additionwas added slowly via syringe
  2. customthe solvent was removed under high vacuum

出典と根拠

ORDレコード
ord-f43a7b016f0d4e24bf5199748fb79bbc
出典データセット
uspto-grants-2014_07
特許番号
US08778977B2

反応ノート

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