HCID 86632947、化合物 → Desmethylselegiline

HRID 1625545ノート

反応式

HRID 1625545 の反応式
Cl.[CH3:2][C@@H:3]([NH2+:11][CH2:12][C:13]#[CH:14])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>ClCCl.C(=O)([O-])[O-].[Na+].[Na+]>[CH3:2][C@@H:3]([NH:11][CH2:12][C:13]#[CH:14])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 1

HCID 86632947HCID 86632947、化合物

生成物 1

HCID 185859Desmethylselegiline

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 10340Sodium Carbonate溶媒

実験手順

840 mg (4 mmol) ((R)-1-methyl-2-phenyl-ethyl)-prop-2-ynyl-ammonium hydrochloride (Sigma) is dissolved in 10 ml dichloromethane and 1M aqueous sodium carbonate. The organic phase is separated. The aqueous phase is extracted three times with 10 ml dichloromathane. The combined organic phases are washed with brine and dried with magnesium sulfate. The crude product 6a is used without further purification.

後処理

  1. customThe organic phase is separated
  2. extractionThe aqueous phase is extracted three times with 10 ml dichloromathane
  3. washThe combined organic phases are washed with brine
  4. dry with materialdried with magnesium sulfate
  5. customThe crude product 6a is used without further purification

出典と根拠

ORDレコード
ord-4564f419b9bf41adb375b33df70200a3
出典データセット
uspto-grants-2014_07
特許番号
US08784775B2

反応ノート

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