Sodium Hydroxide → AM432 sodium

HRID 1625677ノート

反応式

HRID 1625677 の反応式
[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[N:18][C:19]([O:22][CH2:23][CH3:24])=[CH:20][CH:21]=3)[CH:13]=[CH:12][C:11]=2[C:25]2[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([CH2:33][C:34]([OH:36])=[O:35])[CH:26]=2)[CH2:7][CH3:8])=[O:5])[CH2:3][CH2:2]1.[OH-].[Na+:38]>C(O)C>[Na+:38].[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]3[CH:17]=[N:18][C:19]([O:22][CH2:23][CH3:24])=[CH:20][CH:21]=3)[CH:13]=[CH:12][C:11]=2[C:25]2[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([CH2:33][C:34]([O-:36])=[O:35])[CH:26]=2)[CH2:7][CH3:8])=[O:5])[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 50901658AM-432

生成物 1

HCID 50901657AM432 sodium

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

[2′-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid (26.0 g, 53.2 mmol) was dissolved in ethanol (180 mL), sodium hydroxide (53.2 mL, 1N aq.) was added and the reaction was stirred at room temperature for 1 hour. The solution was filtered to remove solid impurities then concentrated. The residue was dissolved in water (˜150 mL) then frozen and lyophilized to afford the title compound.

後処理

  1. filtrationThe solution was filtered
  2. customto remove solid impurities
  3. concentrationthen concentrated
  4. dissolutionThe residue was dissolved in water (˜150 mL)
  5. temperaturethen frozen

出典と根拠

ORDレコード
ord-7a2151900fe24802a73a78c5d42daa99
出典データセット
uspto-grants-2014_07
特許番号
US08785393B2

反応ノート

読み込み中…