Oxalyl chloride → 4-Ethylphenylacetyl chloride

HRID 1625853

反応式

HRID 1625853 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1)[CH3:2].C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C)C=O>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([Cl:16])=[O:12])=[CH:5][CH:4]=1)[CH3:2]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 84403(4-Ethylphenyl)acetic acid

生成物 1

HCID 155783544-Ethylphenylacetyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

4-Ethylphenylacetic acid (3.0 g) (see Japanese Unexamined Patent Publication 63-233975) was dissolved in dichloromethane (15 ml), and thereto were added oxalyl chloride (6.0 ml) and N,N-dimethylformamide (one drop). The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was evaporated under reduced pressure, and the residue was subjected to azeotropic distillation with toluene to give a crude 4-ethylphenylacetyl chloride, which was used in the subsequent step without further purification.

後処理

  1. customThe reaction mixture was evaporated under reduced pressure
  2. distillationthe residue was subjected to azeotropic distillation with toluene

出典と根拠

ORDレコード
ord-31eeafb1227e43058a73a4f990730905
出典データセット
uspto-grants-2014_07
特許番号
US08785403B2

関連ノート

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