Oxalyl chloride → 5-Bromo-2-chlorophenylacetyl chloride

HRID 1625886ノート

反応式

HRID 1625886 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([CH2:8][C:9](O)=[O:10])[CH:7]=1.C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C)C=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([CH2:8][C:9]([Cl:16])=[O:10])[CH:7]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 155124412-(5-Bromo-2-chlorophenyl)acetic acid

生成物 1

HCID 861877695-Bromo-2-chlorophenylacetyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

5-Bromo-2-chlorophenylacetic acid (2.0 g) obtained in Reference Example 125-(3) was dissolved in dichloromethane (40 ml), and thereto were added oxalyl chloride (0.77 ml) and N,N-dimethylformamide (one drop) at 0° C. The mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to give 5-bromo-2-chlorophenylacetyl chloride, which was used in the subsequent step without further purification.

後処理

  1. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-755e648f69ea499297f4824e93a3587a
出典データセット
uspto-grants-2014_07
特許番号
US08785403B2

反応ノート

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