Methanamine, N-methoxy-, hydrochloride (1:1) → 4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide

HRID 1626121

反応式

HRID 1626121 の反応式
[Cl:1][C:2]1[C:3]([C:11]([OH:13])=O)=[N:4][N:5]([CH2:7][CH:8]([F:10])[F:9])[CH:6]=1.Cl.[CH3:15][NH:16][O:17][CH3:18].Cl.CN(C)CCCN=C=NCC>>[CH3:18][O:17][N:16]([CH3:15])[C:11]([C:3]1[C:2]([Cl:1])=[CH:6][N:5]([CH2:7][CH:8]([F:10])[F:9])[N:4]=1)=[O:13]

参加物

4

反応物 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 196228014-Chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylic acid

生成物 1

HCID 866737314-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid methoxy-methyl-amide収率 98%

実験手順

In a manner analogous to that described in Example 1d), the condensation of 4-chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylic acid and N,O-dimethylhydroxylamine hydrochloride by N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride yielded the title compound (98% yield) as a colorless oil. MS (ISP): m/z=254.1 [M+H]+.

出典と根拠

ORDレコード
ord-1e42ec062f344f56aedafe33494cc576
出典データセット
uspto-grants-2014_07
特許番号
US08785436B2

関連ノート

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