Sodium Hydroxide → HCID 68649743、化合物
反応式
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH:14]([F:17])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)C.[OH-].[Na+]>C(O)C>[F:17][CH:14]1[CH2:13][CH2:12][N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:18])=[O:3])=[CH:6][CH:7]=2)[CH2:16][CH2:15]1参加物
4
実験手順
A mixture of 4-(4-fluoro-piperidin-1-yl)benzoic acid ethyl ester (0.7 g, 2.7 mmoles) in ethanol (50 ml) and a solution of 2N sodium hydroxide (20 ml) was stirred at room temperature for 24 hours. The ethanol was then evaporated, the solution diluted with water (20 ml) and neutralized with 2N HCl. The acid separated as a white solid which was washed with water and dried under vacuum (0.52 g, 82%).
後処理
- customThe ethanol was then evaporated
- additionthe solution diluted with water (20 ml)
- customThe acid separated as a white solid which
- washwas washed with water
- customdried under vacuum (0.52 g, 82%)
出典と根拠
- ORDレコード
- ord-36ec72dd1a7448df8f357a2a7d281898
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785448B2
反応ノート
読み込み中…