関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | 5-Amino-4,6-dichloropyrimidine | HCID 79434 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | 6-Chloro-N4-(4-chlorophenyl)pyrimidine-4,5-diamine | HCID 16726311 | 88% |
反応手順
5-amino-4,6-dichloropyrimidine (5.0 g, 30.49 mmol) and 4-chloroaniline (5.1 g, 40.0 mmol) were added to the solution of hydrochloric acid (1.3 mL, 15.24 mmol) in EtOH/H2O (8:1 v/v) (100 ml). The resulting reaction mixture was stirred for overnight at 80° C. The resulting mixture was filtered with NaHCO3(aq)/H2O. The collected solid was dried under reduced pressure to obtain the title compound (6.8 g, 88%) as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08785453B2 |
|---|
| 出典データセット | uspto-grants-2014_07 |
|---|
| ORD ID | ord-d21fcab5b95448b589bb27cca1537fc6 |
|---|
| 出典メモ | uspto-grants-2014_07 |
|---|
