Trifluoroacetic acid → 2-(3,5-Dichloro-pyridin-2-YL)-ethylamine

HRID 1626476ノート

反応式

HRID 1626476 の反応式
[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][NH2:11])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67287275HCID 67287275、化合物

生成物 1

HCID 230682892-(3,5-Dichloro-pyridin-2-YL)-ethylamine収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tert-butyl 2-(3,5-dichloropyridin-2-yl)ethylcarbamate (50 mg, 0.17 mmol) was diluted with DCM (500 uL) followed by the addition of TFA (500 μl). After stirring for 2 hours, the reaction was concentrated and placed under vacuum to yield the desired compound (32 mg, 0.17 mmol, 98% yield).

後処理

  1. concentrationthe reaction was concentrated

出典と根拠

ORDレコード
ord-c27ff43ad9ef4678b90d8450ff1c384c
出典データセット
uspto-grants-2014_07
特許番号
US08785445B2

反応ノート

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