Dimethylamine → 2-(Dimethylamino)-6-(trifluoromethyl)pyridine-3-carbaldehyde

HRID 1626480ノート

反応式

HRID 1626480 の反応式
Cl[C:2]1[N:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:14][NH:15][CH3:16]>C1COCC1>[CH3:14][N:15]([CH3:16])[C:2]1[N:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

4

反応物 2

HCID 674DimethylamineHCID 467399062-Chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde

生成物 1

HCID 582590702-(Dimethylamino)-6-(trifluoromethyl)pyridine-3-carbaldehyde収率 41.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

To a stirred solution of 2-chloro-6-(trifluoromethyl)nicotinaldehyde (115 mg, 0.549 mmol) in THF (1 mL) was added dimethylamine (823 μl, 1.65 mmol). The reaction was heated to 50° C. and stirred for 3 hours. The reaction was loaded onto silica gel and eluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes to yield the desired compound (50 mg, 0.229 mmol, 41.8% yield).

後処理

  1. washeluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-e5492b26e36846f8a75d4a64a613d23f
出典データセット
uspto-grants-2014_07
特許番号
US08785445B2

反応ノート

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