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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Triethylamine → (S)-4-(2-chloro-6-neopentyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-3-methylmorpholine

HRID 1626540

印刷プレビュー

反応式

HRID 1626540 の反応式

Cl.[Cl:2][C:3]1[N:4]=[C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C@@H:13]2[CH3:18])[C:6]2[CH2:11][NH:10][CH2:9][C:7]=2[N:8]=1.[CH3:19][C:20]([CH:23]=O)([CH3:22])[CH3:21].C(N(CC)CC)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C1COCC1.C(OCC)(=O)C.O>[Cl:2][C:3]1[N:4]=[C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][C@@H:13]2[CH3:18])[C:6]2[CH2:11][N:10]([CH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:9][C:7]=2[N:8]=1

参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 8471Triethylamine

HCID 12417Pivalaldehyde

HCID 5049666Sodium triacetoxyborohydride

HCID 86663150(S)-4-(2-chloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-3-methylmorpholine hydrochloride2 回

生成物 1

HCID 86663152(S)-4-(2-chloro-6-neopentyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-3-methylmorpholine

試薬・触媒・溶媒 3

HCID 962Water溶媒

HCID 8028Tetrahydrofuran溶媒

HCID 8857Ethyl Acetate溶媒

実験手順

(S)-4-(2-chloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-3-methylmorpholine hydrochloride (intermediate 6) (163 mg, 0.56 mmol) was stirred in THF (2 mL) with pivaldehyde (0.124 mL, 1.12 mmol) and triethylamine (0.234 mL, 1.68 mmol). After 1 h sodium triacetoxyborohydride (237 mg, 1.12 mmol) was added and the reaction was stirred overnight. Water and ethyl acetate were added. The organic layer was washed (brine) and concentrated in vacuo to give an orange oil, which was used crude.

後処理

washThe organic layer was washed (brine)
concentrationconcentrated in vacuo
customto give an orange oil, which

出典と根拠

ORDレコード: ord-04a6db200b324f7993a9a0b6abf11c14
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08785457B2

反応ノート

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