Hydrochloric Acid → 2-(2-Methanesulfonylamino-benzothiazole-6-yl)-propionic acid ethyl ester

HRID 1626899ノート

反応式

HRID 1626899 の反応式
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([NH2:14])[S:13][C:9]=2[CH:8]=1)[CH3:6])[CH3:2].[CH3:18][S:19](Cl)(=[O:21])=[O:20].Cl>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([NH:14][S:19]([CH3:18])(=[O:21])=[O:20])[S:13][C:9]=2[CH:8]=1)[CH3:6])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 13477940Ethyl 2-amino-alpha-methylbenzothiazole-6-acetate

生成物 1

HCID 577421492-(2-Methanesulfonylamino-benzothiazole-6-yl)-propionic acid ethyl ester

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 4 (347 mg, 1 mmol) in pyridine (3 ml) is added to MsCl (0.13 ml, 1.21 mmol) at room temperature. The reaction mixture is stirred for 14 h at room temperature. 1N HCl (30 ml) is added to the mixture. The mixture extracted with ethyl acetate. The organic layer is dried over magnesium sulfate. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography(n-Hexane:EtOAc).

後処理

  1. extractionThe mixture extracted with ethyl acetate
  2. dry with materialThe organic layer is dried over magnesium sulfate
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash column chromatography(n-Hexane:EtOAc)

出典と根拠

ORDレコード
ord-ef62157892d945c884d7d37318dba27b
出典データセット
uspto-grants-2014_07
特許番号
US08785474B2

反応ノート

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