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Thionyl Chloride → {2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazol-5-yl}methanol

HRID 1627713
ノート
印刷プレビュー

反応式

HRID 1627713 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2([C:27]([F:30])([F:29])[F:28])[CH2:14][CH2:13][N:12]([C:15]3[S:16][C:17]([C:24](O)=[O:25])=[C:18]([C:20]([F:23])([F:22])[F:21])[N:19]=3)[CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8].S(Cl)(Cl)=O>CN(C)C=O.ClCCCl>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2([C:27]([F:30])([F:28])[F:29])[CH2:14][CH2:13][N:12]([C:15]3[S:16][C:17]([CH2:24][OH:25])=[C:18]([C:20]([F:23])([F:22])[F:21])[N:19]=3)[CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 594533662-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 59453386{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazol-5-yl}methanol収率 65%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒
HCID 11
1,2-Dichloroethane
溶媒

実験手順

2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)-1,3-thiazole-5-carboxylic acid (2.2 g) was added to 1,2-dichloroethane (50 mL). Thionyl chloride (1.0 g) and one drop of N,N-dimethylformamide were added to the mixture, which was then refluxed under heating for 5 hours. After removing the solvent by evaporation, the residues were dissolved in 1,4-dioxane (20 mL), and then added dropwise to the mixture solution comprising water (30 mL), 1,4-dioxane (30 mL), and sodium borohydride (0.5 g) under ice cooling. After the dropwise addition was completed, the reaction solution was refluxed under heating for one hour. After cooling, the reaction solution was poured over ice water, and then extracted with ethyl acetate. After cooling, the extraction was again carried out by adding water and ethyl acetate. The organic layer was dried over magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a silica gel chromatography to obtain the title compound (1.1 g, 65%).

後処理

  1. temperaturewas then refluxed
  2. temperatureunder heating for 5 hours
  3. customAfter removing the solvent
  4. customby evaporation
  5. dissolutionthe residues were dissolved in 1,4-dioxane (20 mL)
  6. additionadded dropwise to the mixture solution comprising water (30 mL), 1,4-dioxane (30 mL), and sodium borohydride (0.5 g) under ice cooling
  7. additionAfter the dropwise addition
  8. temperaturethe reaction solution was refluxed
  9. temperatureunder heating for one hour
  10. temperatureAfter cooling
  11. additionthe reaction solution was poured over ice water
  12. extractionextracted with ethyl acetate
  13. temperatureAfter cooling
  14. extractionthe extraction
  15. additionby adding water and ethyl acetate
  16. dry with materialThe organic layer was dried over magnesium sulfate
  17. customThe solvent was evaporated off under reduced pressure
  18. customthe residue was then purified by a silica gel chromatography

出典と根拠

ORDレコード
ord-dfae1ee1f1d6492682e0cff8f9f8f92c
出典データセット
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08785647B2

反応ノート

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