Dimethylformamide → HCID 66597223、化合物

HRID 1627762ノート

反応式

HRID 1627762 の反応式
[NH2:1][C:2]1[S:10][C:5]2[CH2:6][O:7][CH2:8][CH2:9][C:4]=2[C:3]=1[C:11]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)=O.Cl[Si](C)(C)C.CN([CH:28]=[O:29])C>>[CH3:2][C:3]1[C:4]([CH2:5][C:6]([O:29][CH3:28])=[O:7])=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[C:3]2[C:4]3[CH2:9][CH2:8][O:7][CH2:6][C:5]=3[S:10][C:2]=2[N:1]=1

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 6397ChlorotrimethylsilaneHCID 210370773-(4-methylbenzoyl)-4H,5H,7H-thieno[2,3-c]pyran-2-amine

生成物 1

HCID 66597223HCID 66597223、化合物収率 36%

実験手順

This compound was prepared according to the procedure B from (2-amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-yl)-(p-tolyl)-methanone (0.546 g; 2 mmol), methyl levunilate (0.282 mL; 2.2 mmol), chlorotrimethylsilane (1 mL; 8 mmol) in DMF (8 mL) for 22 h. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (2-80%) in heptane furnished 0.270 g (36%) of the title compound as a yellow solid.

後処理

  1. customThis compound was prepared
  2. customPurification by flash chromatography on silica gel using a gradient of ethyl acetate (2-80%) in heptane

出典と根拠

ORDレコード
ord-3329e816dd2f4443a26066d501eabf2e
出典データセット
uspto-grants-2014_07
特許番号
US08785638B2

反応ノート

読み込み中…