Triphenylphosphine → HCID 15758918、化合物
反応式
[Cl:1][C:2]1[C:3]([CH2:9][CH2:10][CH2:11][OH:12])=[C:4](O)[CH:5]=[CH:6][CH:7]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[CH2:9][CH2:10][CH2:11][O:12]2参加物
4
実験手順
To a solution of 3-chloro-2-(3-hydroxypropyl)phenol (0.56 g; 3 mmol) and triphenylphosphine (1.02 g; 3.90 mmol) in tetrahydrofuran (42 mL) was added diisopropyl azadicarboxylate (0.766 mL; 3.90 mmol), the reaction mixture was stirred at room temperature for 4 h and the volatiles were removed under reduced pressure. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (5-80%) in heptane furnished 0.121 g (24%) of 5-chlorochroman.
後処理
- customthe volatiles were removed under reduced pressure
- customPurification by flash chromatography on silica gel using a gradient of ethyl acetate (5-80%) in heptane
出典と根拠
- ORDレコード
- ord-2c3a23a64b074301968dca593d86a714
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785638B2
反応ノート
読み込み中…