3-Phenylphenol → 2-Chloro-6-(3-phenyl-phenyl-oxy)-pyrazine

HRID 16282

反応式

HRID 16282 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C:9]1([C:15]2[CH:16]=[C:17]([OH:21])[CH:18]=[CH:19][CH:20]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCOC(C)=O.C1CCCCC1>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:16]=2)[N:3]=1

参加物

5

反応物 2

HCID 113813-PhenylphenolHCID 785042,6-Dichloropyrazine

生成物 1

HCID 593435012-Chloro-6-(3-phenyl-phenyl-oxy)-pyrazine収率 98%

試薬・触媒・溶媒 2

HCID 8078Cyclohexane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Using Method DD (reaction time: 20 hours) with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 3-phenyl-phenol (268 mg, 1.49 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:2), the title compound was obtained (370 mg). Yield: 98%. 1H NMR (250 MHz, DMSO-d6) δ 7.35-7.72 (m, 9H, Harom), 8.53 (s, 1H, HPz 5), 8.59 (s, 1H, HPz 3). m/z: 283.1 [(M+H)+, calcd for C16H11ClN2O 282.1].

後処理

  1. customMethod DD (reaction time: 20 hours)

出典と根拠

ORDレコード
ord-972732bdf86442079eb9f350a6bbc995
出典データセット
uspto-grants-2010_06
特許番号
US07737152B2

関連ノート

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