Benzoic acid, 3-nitro-5-(4-pyridinyl)-, methyl ester → HCID 67497400、化合物

HRID 1628282ノート

反応式

HRID 1628282 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]

参加物

4

反応物 1

HCID 46317472Benzoic acid, 3-nitro-5-(4-pyridinyl)-, methyl ester

生成物 1

HCID 67497400HCID 67497400、化合物収率 95.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of methyl 3-nitro-5-(pyridin-4-yl)benzoate (45.1.B) (5.60 g, 21.62 mmol) in methanol (50 mL) was added 10% Pd on carbon by weight (2.50 g). The air was evacuated from the reaction flask and was replaced with hydrogen. The resulting slurry was stirred overnight at room temperature. The reaction mixture was then filtered and the mother liquor condensed to afford methyl 3-amino-5-(pyridin-4-yl)benzoate (45.1.C) (4.70 g, 95% yield) which was used in the next step without any further purification.

後処理

  1. customThe air was evacuated from the reaction flask
  2. filtrationThe reaction mixture was then filtered
  3. customthe mother liquor condensed

出典と根拠

ORDレコード
ord-97098eac16c94e6abb8af39ea4354879
出典データセット
uspto-grants-2014_07
特許番号
US08785468B2

反応ノート

読み込み中…