Trifluoroacetic acid → 6-(pyridin-4-yl)indoline TFA salt

HRID 1628292ノート

反応式

HRID 1628292 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][CH2:12][N:13]3C(OC(C)(C)C)=O)=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][CH2:12][NH:13]3)=[CH:9][CH:8]=2)=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69620888tert-Butyl 6-(pyridin-4-yl)indoline-1-carboxylate

生成物 1

HCID 866648356-(pyridin-4-yl)indoline TFA salt収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a 100 ml flask was added tert-butyl 6-(pyridin-4-yl)indoline-1-carboxylate 50.B (202 mg, 0.68), 10 ml of CH2Cl2, and 5 ml of TFA. The reaction was stirred at room temperature for 2 hours at which time the solvent was removed to give 6-(pyridin-4-yl)indoline TFA salt 50.0 as a light yellow solid (300 mg, 100% yield).

後処理

  1. customwas removed

出典と根拠

ORDレコード
ord-30c2f89b6e2a4c9fb1d61638afff5310
出典データセット
uspto-grants-2014_07
特許番号
US08785468B2

反応ノート

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