HCID 67497043、化合物 → HCID 67496690、化合物

HRID 1628294ノート

反応式

HRID 1628294 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([NH2:17])[CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=2)[CH:5]=[CH:4][N:3]=1>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[C:10]([NH2:17])[CH:9]=2)[CH:5]=[CH:4][N:3]=1

参加物

4

反応物 1

HCID 67497043HCID 67497043、化合物

生成物 1

HCID 67496690HCID 67496690、化合物収率 91%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a rt solution of 51.1B (1.10 mg, 4.8 mol) in MeOH (10 mL) was added 5% Pd/C. The heterogeneous solution was stirred at 50° C. under H2 for 4.0 hr. To the resulting mixture was added celite, solid was filtered off and washed with MeOH. The combined liquid was concentrated under reduced pressure to provide the title product 51.1C as colorless solid (865 mg, 91%).

後処理

  1. additionTo the resulting mixture was added celite, solid
  2. filtrationwas filtered off
  3. washwashed with MeOH
  4. concentrationThe combined liquid was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f742faefde4f4870a607373327a9c3ad
出典データセット
uspto-grants-2014_07
特許番号
US08785468B2

反応ノート

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