Tetrahydrofuran → HCID 86632878、化合物
反応式
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].Cl[C:7]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][CH:10]=[CH:9][C:8]=1[N+:16]([O-:18])=[O:17].C(N(CC)CC)C.O1CCCC1>C(OCC)(=O)C>[N+:13]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:16]([O-:18])=[O:17])[C:7]=1[NH:1][CH2:2][CH2:3][CH2:4][OH:5])([O-:15])=[O:14]参加物
6
実験手順
A mixture of 3-amino-1-propanol (6.77 mL, 89.0 mmol), 2-chloro-1,3-dinitrobenzene (15.0 g, 74.1 mmol), triethylamine (12.4 mL, 89.0 mmol) and tetrahydrofuran (370 mL) was stirred at room temperature for 12 hr. The reaction mixture was diluted with ethyl acetate, washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the title compound as a solid (17.7 g, 73.3 mmol, 99%).
後処理
- washwashed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-176e97540bf9498bb05132951409f6e9
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785460B2
反応ノート
読み込み中…