3,4,5-Trimethoxyaniline → 6-(2-fluorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

反応式

Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[N:3]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:22]=[C:23]([O:27][CH3:28])[C:24]=1[O:25][CH3:26])[NH2:21]>CCOC(C)=O.C1CCCCC1>[CH3:28][O:27][C:23]1[CH:22]=[C:20]([NH:21][C:2]2[CH:7]=[N:6][CH:5]=[C:4]([O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[F:15])[N:3]=2)[CH:19]=[C:18]([O:17][CH3:16])[C:24]=1[O:25][CH3:26]

参加物

実験手順

Using Method EE with 2-chloro-6-(2-fluorophenyloxy)-pyrazine (200 mg, 0.89 mmol) and 3,4,5-trimethoxyaniline (196 mg, 1.07 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (234 mg). Yield: 71%. 1H NMR (250 MHz, DMSO-d6) δ 3.42 (s, 6H, [CH3O]3+5), 3.54 (s, 3H, [CH3O]4), 6.69 (s, 2H, Harom2′+6′), 7.24-7.41 (m, 4H, Harom), 7.83 (s, 1H, HPz 5), 7.96 (s, 1H, HPz 3), 9.57 (s, 1H, NH).