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Acetic Acid → 1-{5-[1-(4-Chloro-3-methyl-phenyl)-propylamino]-2-methyl-benzyl}-azetidine-3-carboxylic acid

HRID 1629706
ノート
印刷プレビュー

反応式

HRID 1629706 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([CH3:20])=[C:16]([CH:19]=2)[CH:17]=O)[CH2:9][CH3:10])=[CH:4][C:3]=1[CH3:21].[NH:22]1[CH2:25][CH:24]([C:26]([OH:28])=[O:27])[CH2:23]1.CC(O)=O.[BH3-]C#N.[Na+]>CO.C([O-])(O)=O.[Na+]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([CH3:20])=[C:16]([CH:19]=2)[CH2:17][N:22]2[CH2:25][CH:24]([C:26]([OH:28])=[O:27])[CH2:23]2)[CH2:9][CH3:10])=[CH:4][C:3]=1[CH3:21]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 176Acetic AcidHCID 931923-azetidinecarboxylic AcidHCID 5003444Sodium cyanoborohydrideHCID 575173205-[1-(4-Chloro-3-methyl-phenyl)-propylamino]-2-methyl-benzaldehyde

生成物 1

HCID 533403201-{5-[1-(4-Chloro-3-methyl-phenyl)-propylamino]-2-methyl-benzyl}-azetidine-3-carboxylic acid

試薬・触媒・溶媒 2

HCID 887
Methanol
溶媒
HCID 516892Sodium Bicarbonate溶媒

実験手順

To a solution of INT 9 (200 mg, 0.66 mmol) and azetidine-3-carboxylic acid (67 mg, 0.66 mmol) in MeOH (6.5 mL) was added HOAc (0.038 mL, 0.66 mmol) followed by NaCNBH3 (42 mg, 0.66 mmol). The reaction mixture was stirred at room temperature for 1 hour. The mixture was diluted with saturated aqueous NaHCO3 and extracted with CH2Cl2 (2×). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by preparative HPLC (H2O/CH3CN) to afford the title compound Example 4.

後処理

  1. extractionextracted with CH2Cl2 (2×)
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was purified by preparative HPLC (H2O/CH3CN)

出典と根拠

ORDレコード
ord-2e74b885148c4478b1b2e7df4e931475
出典データセット
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08791100B2

反応ノート

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