Thionyl Chloride → HCID 66836706、化合物

HRID 1631142ノート

反応式

HRID 1631142 の反応式
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=1[CH2:14]O>ClCCl>[Br:5][C:6]1[CH:11]=[C:10]([F:12])[C:9]([F:13])=[CH:8][C:7]=1[CH2:14][Cl:3]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 57518297(2-Bromo-4,5-difluorophenyl)methanol

生成物 1

HCID 66836706HCID 66836706、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
25 °C

実験手順

146 μl of thionyl chloride in 2.5 ml of dichloromethane are added dropwise to 300 mg of (2-bromo-4,5-difluorophenyl)methanol in 2.5 ml of dichloromethane, and the mixture is stirred at 25° C. for 2 h. The mixture is evaporated to dryness in vacuo, the residue is taken up in 10 ml of toluene, and the operation is repeated. The residue is employed in the subsequent reactions without further treatment.

後処理

  1. customThe mixture is evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-519333e6eb1048c18375e7995c396d7b
出典データセット
uspto-grants-2014_07
特許番号
US08791129B2

反応ノート

読み込み中…