Water → (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol hydrochloride

HRID 1631843ノート

反応式

HRID 1631843 の反応式
[CH3:1][N:2]([CH3:17])[CH2:3][C@H:4]([O:15][CH3:16])[C@@H:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7].O.C[Si](C)(C)[Cl:21]>CC(=O)CC>[ClH:21].[CH3:17][N:2]([CH3:1])[CH2:3][C@H:4]([O:15][CH3:16])[C@@H:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

参加物

5

反応物 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 86690044(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol

生成物 1

HCID 86690045(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol hydrochloride

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

反応条件

温度
22.5 °C

実験手順

Part of the oil obtained in Example 6 is dissolved in 2-butanone (40 mL) at the temperature of 20-25° C. The following are added: purified water (0.3 mL, 0.0167 moles), trimethylchlorosilane (1.2 g). The hydrochloride product precipitates and the suspension is maintained under stirring for 4 hours at the temperature of 20-25° C. Finally, the solid is filtered, and this is dried under vacuum at 30-40° C.

後処理

  1. additionThe following are added
  2. customThe hydrochloride product precipitates
  3. temperaturethe suspension is maintained
  4. filtrationFinally, the solid is filtered
  5. customthis is dried under vacuum at 30-40° C.

出典と根拠

ORDレコード
ord-986abd2bc89640a481ddf60562d29772
出典データセット
uspto-grants-2014_07
特許番号
US08791287B2

反応ノート

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