Methyl vinyl ketone → Spiro(4.5)dec-6-ene-8-one

HRID 1631850

反応式

HRID 1631850 の反応式
[CH:1]1([CH:6]=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:8]([C:10]([CH3:12])=[O:11])=[CH2:9]>>[CH2:2]1[C:1]2([CH2:6][CH2:12][C:10](=[O:11])[CH:8]=[CH:9]2)[CH2:5][CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 6570Methyl vinyl ketoneHCID 70106Cyclopentanecarbaldehyde

生成物 1

HCID 139772Spiro(4.5)dec-6-ene-8-one収率 54%

実験手順

Piperidine enamine was prepared by a method analogous to that described in Organic Syntheses, Collective Volume 7, p 473, using 221.84 g of cyclopentane carbaldehyde instead of cyclooctane carbaldehyde. Through Michael addition of piperidine enamine to methyl vinyl ketone, cyclization by aldol condensation, dehydration, hydrolysis, and vacuum distillation for purification, there was obtained 173.4 g (yield 54%) of spiro[4.5]dec-6-en-8-one.

後処理

  1. customby aldol condensation, dehydration, hydrolysis, and vacuum distillation
  2. customfor purification

出典と根拠

ORDレコード
ord-c5f62ab611364ee3909ce0b58766bf29
出典データセット
uspto-grants-2014_07
特許番号
US08791288B2

関連ノート

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