Formic Acid → tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate

HRID 1631972ノート

反応式

HRID 1631972 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(O)=O>CO.[Pd]>[N:14]1([CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]2)[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1

参加物

5

反応物 2

HCID 284Formic AcidHCID 18971584Benzyl 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)piperazine-1-carboxylate

生成物 1

HCID 17750358tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of 3.01 g (7.46 mmol) of benzyl 4-(1-tert-butoxycarbonylpiperidin-4-yl)piperazine-1-carboxylate and 300 mg of Pd—C (5%) in 100 ml of methanol was mixed with 4 ml of formic acid and stirred under a hydrogen atmosphere (1 bar) at room temperature overnight. The reaction mixture was filtered through Celite, the residue on the filter was washed with methanol, and the solvent was then removed in vacuo. The residue was used without further purification in the next reaction step.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe residue on the filter was washed with methanol
  3. customthe solvent was then removed in vacuo
  4. customThe residue was used without further purification in the next reaction step

出典と根拠

ORDレコード
ord-8ba3f999a16d423eaadad235ef330b09
出典データセット
uspto-grants-2014_07
特許番号
US08791148B2

反応ノート

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