Methanol → Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

HRID 1632118ノート

反応式

HRID 1632118 の反応式
[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4](Cl)=[O:5].C(N(CC)CC)C.[CH3:16][OH:17]>>[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([O:17][CH3:16])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 8471TriethylamineHCID 613453-Chloro-2,2-dimethylpropanoyl chloride

生成物 1

HCID 543185Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

実験手順

219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was mixed with water and extracted with ether. The extract was dried (MgSO4), and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (3A), b.p.: 40°-50° C. (14 Torr.).

後処理

  1. temperaturea chilled (0°-5° C.)
  2. custommost of the methanol was evaporated under reduced pressure
  3. additionThe residue was mixed with water
  4. extractionextracted with ether
  5. dry with materialThe extract was dried (MgSO4)
  6. customthe solvent was evaporated
  7. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-c7a50dcc66724a2796590abdda9c6f3b
出典データセット
uspto-grants-1984_10
特許番号
US04474598

反応ノート

読み込み中…