Chloroacetyl chloride → N-(3-Fluorophenyl)-alpha-chloroacetanilide
反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]=[CH:6][CH:7]=1.[Cl:15][CH2:16][C:17](Cl)=[O:18]>C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([N:8]([C:17](=[O:18])[CH2:16][Cl:15])[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
N-(3-Fluorophenyl)aniline (7.02 g, 0.0375 mole) and chloroacetyl chloride (3.3 ml, 0.0412 mole) were refluxed in benzene (50 ml) for 3 hours, then evaporated in vacuo to solids and the solids triturated with pentane and ether to yield purified title product, 8.69 g, m.p. 115°-117°.
後処理
- customevaporated in vacuo to solids
- customthe solids triturated with pentane and ether
- customto yield
- custompurified title product, 8.69 g, m.p. 115°-117°
出典と根拠
- ORDレコード
- ord-6dade336d7684720af298e17b9db9792
- 出典データセット
- uspto-grants-1984_10
- 特許番号
- US04476307
反応ノート
読み込み中…