Hydrazine hydrate (1:1) → Endralazine

HRID 1633036ノート

反応式

HRID 1633036 の反応式
[C:1]([N:9]1[CH2:19][CH2:18][C:12]2[N:13]=[N:14][C:15](Cl)=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:21][NH2:22]>>[C:1]([N:9]1[CH2:19][CH2:18][C:12]2[N:13]=[N:14][C:15]([NH:21][NH2:22])=[CH:16][C:11]=2[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 12582765HCID 12582765、化合物

生成物 1

HCID 47608Endralazine

実験手順

A suspension of 21.6 g of 6-benzoyl-3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine in 80 cc of hydrazine hydrate is boiled at reflux at an oil bath temperature of 110° for 1 hour. After a reaction time of approximately 15 minutes the material dissolves completely. The crude title compound resulting after cooling the mixture, is washed with a small amount of absolute ethanol and dissolved in 60 cc of dimethyl formamide. 60 cc of absolute ethanol are added to the solution, whereupon the title compound crystallizes.

後処理

  1. temperatureat reflux at an oil bath temperature of 110° for 1 hour
  2. dissolutionAfter a reaction time of approximately 15 minutes the material dissolves completely

出典と根拠

ORDレコード
ord-42ad74e2cb9f491db7485b14e38898e0
出典データセット
uspto-grants-1984_10
特許番号
US04478837

反応ノート

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