Thionyl Chloride → (4-Fluorophenoxy)acetyl chloride
反応式
[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8](O)=[O:9])=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([Cl:15])=[O:9])=[CH:4][CH:3]=1参加物
4
実験手順
Into a 100 ml round bottom flask equipped with a magnetic stirrer, reflux condenser equipped with a connector to a 50% sodium hydroxide trap, 6.81 g (0.040 mole) para-fluorophenoxyacetic acid (the product of Example 2), 2.96 ml (0.044 mole) thionyl chloride, and about 40 ml toluene. The reaction mixture was stirred at reflux for two hours, allowed to cool to room temperature, and then concentrated to give 7.2 g of the product, a brwon liquid.
後処理
- customInto a 100 ml round bottom flask equipped with a magnetic stirrer
- temperaturereflux condenser
- customequipped with a connector to a 50% sodium hydroxide trap
- temperatureat reflux for two hours
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8c2280aef46a4fe7ab60c4afd38eef12
- 出典データセット
- uspto-grants-1984_10
- 特許番号
- US04479900
反応ノート
読み込み中…