Ethyl 4-chlorobutyrate → 3-Acetyl-2-[2-[3-(ethoxycarbonyl)-propoxy]phenyl]benzothiazoline

HRID 1633242

反応式

HRID 1633242 の反応式
[H-].[Na+].[C:3]([N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8][CH:7]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21])(=[O:5])[CH3:4].Cl[CH2:23][CH2:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>CN(C=O)C>[C:3]([N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8][CH:7]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])(=[O:5])[CH3:4]

参加物

5

反応物 3

HCID 18474Ethyl 4-chlorobutyrateHCID 24758Sodium hydrideHCID 133359603-Acetyl-2-(2-hydroxyphenyl)benzothiazoline

生成物 1

HCID 135642173-Acetyl-2-[2-[3-(ethoxycarbonyl)-propoxy]phenyl]benzothiazoline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒3 回

実験手順

To the suspension of 1.59 g of sodium hydride in 30 ml of anhydrous DMF, the solution of 8.13 g of 3-acetyl-2-(2-hydroxyphenyl)benzothiazoline in 30 ml of anhydrous DMF is added dropwise under nitrogen atmosphere at room temperature. After the addition, the reaction mixture is stirred for 20 minutes at room temperature. To the reaction mixture, the solution of 4.95 g of ethyl 4-chlorobutyrate in 15 ml of anhydrous DMF is added and stirred for 5 hours at 70° C. After cooling to room temperature the reaction mixture is poured into ice-water and extracted with ethyl acetate.

後処理

  1. additionAfter the addition
  2. stirringstirred for 5 hours at 70° C
  3. temperatureAfter cooling to room temperature the reaction mixture
  4. extractionextracted with ethyl acetate

出典と根拠

ORDレコード
ord-c5771f61252e4acf97aad10b32e1b75f
出典データセット
uspto-grants-1984_10
特許番号
US04479949

関連ノート

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