Paroxetine → Paroxetine Hydrochloride

HRID 1633551

反応式

HRID 1633551 の反応式
CCOC1C(OCCN[C@@H](CC2C=CC(OC)=C(S(N)(=O)=O)C=2)C)=CC=CC=1.[ClH:29].[K+].[Br-].[CH:32]1[C:37]([C@H:38]2[C@H:43]([CH2:44][O:45][C:46]3[CH:47]=[CH:48][C:49]4[O:54][CH2:53][O:52][C:50]=4[CH:51]=3)[CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:36][CH:35]=[C:34]([F:55])[CH:33]=1>>[CH:36]1[C:37]([C@H:38]2[C@H:43]([CH2:44][O:45][C:46]3[CH:47]=[CH:48][C:49]4[O:54][CH2:53][O:52][C:50]=4[CH:51]=3)[CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:32][CH:33]=[C:34]([F:55])[CH:35]=1.[ClH:29]

参加物

4

反応物 3

HCID 43815ParoxetineHCID 253877Potassium BromideHCID 5362376Tamsulosin Hydrochloride

生成物 1

HCID 62878Paroxetine Hydrochloride

実験手順

The composition of the solid product was tested by Fourier Transform Infra Red (FTIR) technique. A Nicolet Magna IR System 750 Fourier Transform Infrared Spectrometer controlled via Nicolet Omnic ESP® software was used to obtain the spectra. A KBr beamsplitter was used and data was collected over 4000−400 cm−1 with a resolution of 4 cm−1. An MCT-A detector, cooled with liquid nitrogen, was used. The sample compartment was under constant nitrogen purge. The aperture was set at 28, the micro velocity was 1.8988 and the gain setting was 1. The contact; sampler attachment, which is a horizontal internal reflection accessory, with a trough cell, containing the ZnSe 45° ATR crystal, was used. The background spectrum was air. The spectrum was obtained by averaging 100 scans. The findings were consistent with published spectra for paroxetine.

後処理

  1. customto obtain the spectra
  2. customdata was collected over 4000−400 cm−1 with a resolution of 4 cm−1
  3. temperatureAn MCT-A detector, cooled with liquid nitrogen
  4. custompurge
  5. additionwith a trough cell, containing the ZnSe 45° ATR crystal
  6. customThe spectrum was obtained

出典と根拠

ORDレコード
ord-5243083d97fd40408c33c200c0c54329
出典データセット
uspto-grants-2003_01
特許番号
US06503927B1

関連ノート

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