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基本情報
- CAS
106463-17-6- 標準SMILES
CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1.Cl- InChIKey
ZZIZZTHXZRDOFM-XFULWGLBSA-N- 分子式
- C20H29ClN2O5S
- 平均分子量
- 445 g/mol
- 単同位体質量
- 444.14857071
概要
Tamsulosin hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of tamulosin and hydrogen chloride. It has a role as an antineoplastic agent and an alpha-adrenergic antagonist. It contains a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin hydrochloride.
名称と識別子
- 優先名称
- Tamsulosin Hydrochloride
- IUPAC
- 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride
名称と別名
TAMSULOSIN HYDROCHLORIDE106463-17-6Tamsulosin HClHarnalPradifYM617LY253351R-(-)-YM-12617DTXSID2046628Flomax MRYM-12617-1LY-253351
名称をさらに表示
11SV1951MR(-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochlorideR-(-)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochlorideCHEBI:9399DTXCID0026628Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-JALYN COMPONENT TAMSULOSIN HYDROCHLORIDEDiffundox
データベース識別子
- CAS
106463-17-6- PubChem CID
- 5362376
- DTXSID
DTXSID2046628- ChEMBL
CHEMBL1200914- ChEBI
CHEBI:9399- UNII
- 11SV1951MR
- EC Number
- 629-756-5
物性
構造計算による物性補完中
- 極性表面積
- 108 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 7
- 回転可能結合数
- 11
- 重原子数
- 29
- 形式電荷
- 0
- 複雑度
- 539
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
GHS分類
GHS Classification
Warning
H302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 133 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 4 (99.2%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Tamsulosin hydrochloride
vLess-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
化学と産業
薬理情報
FDA Pharmacological Classification
TAMSULOSIN HYDROCHLORIDE
Adrenergic alpha-Antagonists [MoA]; alpha-Adrenergic Blocker [EPC]
MeSH Pharmacological Classification
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS.
関連反応
6 件
化合物ノート
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