Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine

HRID 1633576ノート

反応式

HRID 1633576 の反応式
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl.CO>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 15512821HCID 15512821、化合物

生成物 1

HCID 155128224-(5-Fluoro-2-methoxyphenyl)piperidine

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) was dissolved in HCl (16 mL, 0.5 N) and MeOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.

後処理

  1. temperatureto reflux for 16 hours
  2. extractionextracted with EtOAc (3×25 mL)

出典と根拠

ORDレコード
ord-179f056309ed4aac9714856b40099491
出典データセット
uspto-grants-2003_01
特許番号
US06503928B2

反応ノート

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