Sodium Hydroxide → Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine

HRID 1633628ノート

反応式

HRID 1633628 の反応式
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)=O)(C)(C)C.[OH-].[Na+]>CCO>[CH2:25]([N:22]([CH2:23][CH3:24])[CH2:21][CH2:20][CH2:19][CH2:18][O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[NH:8][CH:9]=[CH:10]2)[CH3:26]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 695488375-(4-Diethylamino-butoxy)-indole-1-carboxylic acid tert-butyl ester

生成物 1

HCID 18679455Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3.9 g (10.8 mmol) 5-(4-Diethylamino-butoxy)-indole-1-carboxylic acid tert-butyl ester in 4 ml EtOH were treated with 0.4 ml halfconc. NaOH at 60° C. for 2 h. The suspension was concentrated in vacuo and the residue dissolved in EtOAc and water. The organic phase was washed with water and dried over Na2SO4. Evaporation yielded 2.7 g (96%) Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine as brown oil, MS: 261 (MH+).

後処理

  1. concentrationThe suspension was concentrated in vacuo
  2. dissolutionthe residue dissolved in EtOAc
  3. washThe organic phase was washed with water
  4. dry with materialdried over Na2SO4
  5. customEvaporation

出典と根拠

ORDレコード
ord-a70007d2915c45308cae53b33c0735f6
出典データセット
uspto-grants-2003_01
特許番号
US06503907B2

反応ノート

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