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Ammonium Chloride → 4-(1-hydroxy-6-methoxy-5-nitro-1,2,3,4-tetrahydro-1-naphthalenyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | N,N-Dimethyl 4-iodo-1H-imidazole-1-sulfonamide | HCID 2773390 | — |
| 反応物 | 6-Methoxy-5-nitro-1,2,3,4-tetrahydronaphthalen-1-one | HCID 13067337 | — |
| 反応物 | HCID 178418443 | HCID 178418443 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(1-hydroxy-6-methoxy-5-nitro-1,2,3,4-tetrahydro-1-naphthalenyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide | HCID 18679742 | — |
反応手順
A solution of 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (3.0 g, 10 mmol) (R. M. Turner, J. Org. Chem. (1991), 56, 5739-5740) in dichloromethane (40 mL) was treated with ethyl magnesium bromide (3.0M in diethyl ether, 3.3 mL) over 5 minutes, stirred for 30 minutes, treated with 6-methoxy-5-nitro-1-tetralone (2.6 g, 11.8 mmol), stirred for 16 hours, treated with ammonium chloride solution and extracted with dichloromethane. The extract was dried (MgSO4), filtered and concentrated to provide the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06503935B1 |
| 出典データセット | uspto-grants-2003_01 |
| ORD ID | ord-ef094213dff74786b4547236844aa51b |
| 出典メモ | uspto-grants-2003_01 |