[(3'S)-1'-[(tert-butoxy)carbonyl]-2-oxo-[1,3'-bipyrrolidin]-3-yl]triphenylphosphanium bromide → HCID 12993648、化合物

HRID 1633812ノート

反応式

HRID 1633812 の反応式
[Br-].[C:2]([O:6][C:7]([N:9]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][CH:16]([P+](C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:15]2=[O:38])[CH2:10]1)=[O:8])([CH3:5])([CH3:4])[CH3:3].C(O[K])(C)(C)C.C([O:58][C:59]([C:61]1[N:62]2[CH:65]([S:66][CH2:67][C:68]=1[CH:69]=O)[CH:64]([NH:71][C:72](=[O:101])[C:73]([C:95]1[N:99]=[C:98]([NH2:100])[S:97][N:96]=1)=[N:74][O:75][C:76]([C:89]1[CH:94]=[CH:93][CH:92]=[CH:91][CH:90]=1)([C:83]1[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=1)[C:77]1[CH:82]=[CH:81][CH:80]=[CH:79][CH:78]=1)[C:63]2=[O:102])=[O:60])(C1C=CC=CC=1)C1C=CC=CC=1>ClCCl.C1(C)C=CC=CC=1.C1COCC1>[NH2:100][C:98]1[S:97][N:96]=[C:95](/[C:73](=[N:74]/[O:75][C:76]([C:89]2[CH:90]=[CH:91][CH:92]=[CH:93][CH:94]=2)([C:83]2[CH:84]=[CH:85][CH:86]=[CH:87][CH:88]=2)[C:77]2[CH:82]=[CH:81][CH:80]=[CH:79][CH:78]=2)/[C:72]([NH:71][C@@H:64]2[C:63](=[O:102])[N:62]3[C@@H:65]2[S:66][CH2:67][C:68](/[CH:69]=[C:16]2/[C:15](=[O:38])[N:14]([C@@H:11]4[CH2:12][CH2:13][N:9]([C:7]([O:6][C:2]([CH3:3])([CH3:4])[CH3:5])=[O:8])[CH2:10]4)[CH2:18][CH2:17]/2)=[C:61]3[C:59]([OH:60])=[O:58])=[O:101])[N:99]=1

参加物

7

反応物 3

HCID 10167480[(3'S)-1'-[(tert-butoxy)carbonyl]-2-oxo-[1,3'-bipyrrolidin]-3-yl]triphenylphosphanium bromideHCID 731640087-[2-(5-Amino-[1,2,4]thiadiazol-3-yl)-2-trityloxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl esterHCID 178418922HCID 178418922、化合物

生成物 1

HCID 12993648HCID 12993648、化合物収率 50.4%

試薬・触媒・溶媒 3

HCID 1140Toluene溶媒HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

4.2 (small scale): To a solution of 2.45 g of (1′-tert.-butoxycarbonyl-2-oxo-[1,3′]-bipyrrolidinyl-3-(R,S)-yl)-triphenyl-phosphonium bromide (preparation according EP 1 067 131 A1) in 6 ml of dichloromethane and 15 ml of toluene was added at −78° C. a solution of 432 mg of t-C4H9OK in 6 ml of THF over 10 min and stirring was continued at −78° C. for 10 min. The solution was treated at −78° C. with a solution of 3.50 g 7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-trityloxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester in 6 ml of THF over 15 min and stirring was continued at −78° C. for 6 h and at −50° C. for 1 h after which time HPLC showed almost completion of the reaction. The reaction was quenched with a solution of 0.95 g of citric acid in 9 ml of water followed by addition of 12 ml of ethyl acetate, the organic layer was washed with NaHCO3 and brine, dried over MgSO4, filtered and the filtrate was evaporated. The residue was chromatographed on silica with ethyl acetate/hexane 10:1 to give 1.82 g of the title compound as a foam. IR (Nujol): 3450 m (NH2, NH), 1779 s, 1724 s, 1678 s, 1653 s (C═O). 1H-NMR (d6-DMSO): 9.93 (d, J=8.8, 1H, NH); 8.13 (s, br., 2H, NH2); 7.6-7.3 (m, 26H, H—ar., HC—C(3)); 6.96 (s, 1H, CH(Ph)2); 6.15 (dd, J=8.8 and 4.8, 1H, H—C(7)); 5.33 (d, J=4.8, 1H, H—C(6)); 4.59 (m, 1H, CH—N)); 3.91, 3.85 (d each, J=18 each, 2H, CH2—S(5)); 3,5-3,3 and 2.9 and 2.7 and 2.0 (m each, 6H and 1H and 1H and 2H, 5×CH2); 1.41 (s, 9H, (CH3)3C). MS (CI): 1044/100 (M+H+).

後処理

  1. stirringstirring
  2. waitwas continued at −78° C. for 6 h and at −50° C. for 1 h
  3. customcompletion of the reaction
  4. customThe reaction was quenched with a solution of 0.95 g of citric acid in 9 ml of water
  5. additionfollowed by addition of 12 ml of ethyl acetate
  6. washthe organic layer was washed with NaHCO3 and brine
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. customthe filtrate was evaporated
  10. customThe residue was chromatographed on silica with ethyl acetate/hexane 10:1

出典と根拠

ORDレコード
ord-16c8e63495e74157824eab25b13423d9
出典データセット
uspto-grants-2003_01
特許番号
US06504025B2

反応ノート

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