Methyl 3-isocyanatobenzoate → 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester

HRID 1633972

反応式

HRID 1633972 の反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]=[C:11]=[O:12])[CH:5]=1.[C:14]([C:18]1[CH:23]=[CH:22][C:21]([NH:24][CH2:25][C:26]2[CH:39]=[CH:38][C:29]([C:30]([NH:32][C:33]3[N:34]=[N:35][NH:36][N:37]=3)=[O:31])=[CH:28][CH:27]=2)=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>ClC(Cl)C>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]([N:24]([C:21]2[CH:20]=[CH:19][C:18]([C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:23][CH:22]=2)[CH2:25][C:26]2[CH:27]=[CH:28][C:29]([C:30](=[O:31])[NH:32][C:33]3[N:34]=[N:35][NH:36][N:37]=3)=[CH:38][CH:39]=2)=[O:12])[CH:5]=1

参加物

4

反応物 2

HCID 2733366Methyl 3-isocyanatobenzoateHCID 225017634-[(4-tert-butylphenylamino)methyl]-N-(2H-tetrazol-5-yl)benzamide

生成物 1

HCID 538709223-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

反応条件

温度
25 °C

実験手順

2.50 mmol 3-isocyanatobenzoic acid methyl ester dissolved in 5 mL dichloroethane was added to the above resin 4-[(4-tert-butylphenylamino)methyl]-N-(2H-tetrazol-5-yl)benzamide (500 mg). Shaking the mixture 5 hours at 25° C. followed by filtration and washing of the resin with dichloromethane (2×10 mL), DMF (2×10 mL) and THF (3×10 mL) afforded the resin bound title compound.

後処理

  1. filtrationfollowed by filtration
  2. washwashing of the resin with dichloromethane (2×10 mL), DMF (2×10 mL) and THF (3×10 mL)
  3. customafforded the resin

出典と根拠

ORDレコード
ord-97b99f94c08c4c54a2400a3e821e10e5
出典データセット
uspto-grants-2003_01
特許番号
US06503949B1

関連ノート

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