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HRID 1633972作成日：2026年10月26日
Methyl 3-isocyanatobenzoate → 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester
https://huagongshe.com/reaction/1633972
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 3-isocyanatobenzoate | HCID 2733366 | — |
| 反応物 | 4-[(4-tert-butylphenylamino)methyl]-N-(2H-tetrazol-5-yl)benzamide | HCID 22501763 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester | HCID 53870922 | — |
反応手順
2.50 mmol 3-isocyanatobenzoic acid methyl ester dissolved in 5 mL dichloroethane was added to the above resin 4-[(4-tert-butylphenylamino)methyl]-N-(2H-tetrazol-5-yl)benzamide (500 mg). Shaking the mixture 5 hours at 25° C. followed by filtration and washing of the resin with dichloromethane (2×10 mL), DMF (2×10 mL) and THF (3×10 mL) afforded the resin bound title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06503949B1 |
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| 出典データセット | uspto-grants-2003_01 |
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| ORD ID | ord-97b99f94c08c4c54a2400a3e821e10e5 |
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| 出典メモ | uspto-grants-2003_01 |
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