反应详情

温度

25 °C

2.50 mmol 3-isocyanatobenzoic acid methyl ester dissolved in 5 mL dichloroethane was added to the above resin 4-[(4-tert-butylphenylamino)methyl]-N-(2H-tetrazol-5-yl)benzamide (500 mg). Shaking the mixture 5 hours at 25° C. followed by filtration and washing of the resin with dichloromethane (2×10 mL), DMF (2×10 mL) and THF (3×10 mL) afforded the resin bound title compound.

1. filtrationfollowed by filtration
2. washwashing of the resin with dichloromethane (2×10 mL), DMF (2×10 mL) and THF (3×10 mL)
3. customafforded the resin