Dimethylamine → 4-(bromomethyl)-N,N-dimethylbenzamide

反応式

[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[N:12]1[CH:17]=CC=C[CH:13]=1.CNC>>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:12]([CH3:17])[CH3:13])=[O:8])=[CH:5][CH:4]=1

参加物

反応物 3

HCID 674Dimethylamine

HCID 1049Pyridine

HCID 50682894-Bromomethyl-benzoyl chloride

生成物 1

HCID 186770234-(bromomethyl)-N,N-dimethylbenzamide収率 99.7%

反応条件

温度: 23 °C

実験手順

A mixture of 4-bromomethyl-benzoyl chloride (7.0 g, 30.24 mmol), polyvinyl pyridine (9.6 g, 90.7 mmol) and dimethyl amine (15.9 ml, 31.8 mmol, 2.0 M in THF) was stirred at 23° C. for 15 h. The solution was filtered and the solvent removed to give 7.3 g (99% yield) of 4-bromomethyl-N,N-dimethyl-benzamide as a yellow solid.